Malignant transformation of Madelung?s disease in a patient with a coincidental diagnosis of breast cancer: a case report

Case Report

Maddalena Borriello, Alessandro Lucidi, Arnaldo Carbone, Vito Iannone and Gabriella Ferrandina

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Diagnostic Pathology 2012, 7:116?doi:10.1186/1746-1596-7-116

Published: 1 September 2012

Abstract (provisional)

Madelung's disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung's disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung's disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer.

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Source: http://www.diagnosticpathology.org/content/7/1/116

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